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[[File:Propranolol-2D-skeletal.png|thumb|[[Kalanseng formula]] ning[[propranolol]], ing mumunang migluid a clinical beta blocker]]
Deng '''Beta blockers''' (neng misan misusulat bilang '''β-blocker''') metung lang pinduan a [[medication|panulu]] a gagamitan da kareng miyayaliwang signus, dapot lalung lalu na keng pamanalan o pamangasiwa keng [[cardiac arrhythmia]] ampong pamaningat keng pusu kaibat ning [[myocardial infarction]]. Inya iti ing mumunang pamanulu keng matas a prisyun o [[hypertension]], deng karelang agagawa mebawas a alaga inyang Juniu [[2006]] ning [[United Kingdom]] keng pang-apat a gulis a nung nu ela mabisa kalupa da reng aliwang panulu, lalu da kareng mangatuang atin [[erectile dysfunction]] ampong [[Steatorrhea|manalas a pitaklan]], ampong darakal ing katibayan na deng maralas a magagamit a beta-blockers lalunglaluna deng piayabe kareng [[thiazide]]-a pinduan a [[diuretic]]s a maging sangkan ing mikaka [[Diabetes mellitus type 2|type 2 diabetes]] la.<ref name="ref1">{{cite web | author= Sheetal Ladva | title=NICE and BHS launch updated hypertension guideline | url=http://www.nelm.nhs.uk/Record%20Viewing/viewRecord.aspx?id=567178 | date=28/06/2006 | publisher=[[National Institute for Health and Clinical Excellence]] | accessdate=2006-09-30}}</ref>

Ing [[Propranolol]] iya ing mumunang diling clinically a gamitan a  beta adrenergic [[receptor antagonist]]. Inimbentu neng Sir [[James W. Black]], iti elilan na ing pamangasiwa  keng pamanulu keng  [[angina pectoris]] ampong iti ing pekamaulagang ambag keng clinical a pamanulu ampong keng [[pharmacology]] ngening pang20ng dilanua.<ref name="propranolol">{{cite web | year=1997 | url=http://texasheart.org/Education/THIJournal/SIRJAMES.cfm | author=Melanie Patricia Stapleton | title=Sir James Black and Propranolol | publisher=Texas Heart Institute Journal | accessdate=2008-04-16 | archivedate=2006-09-04 | archiveurl=https://web.archive.org/web/20060904225429/http://texasheart.org/Education/THIJournal/SIRJAMES.cfm }}</ref>

Deng Beta blockers malyari la naman idaleraya bilang '''beta-adrenergic pangsabagal a agenti''', '''beta-adrenergic panglaban''', o kaya '''beta panglaban'''.

== Pharmacology ==
Deng Beta blockers sasabatan na ing gawa ning  [[endogenous]] [[catecholamine]]s ([[epinephrine]] ([[adrenaline]]) ampong [[norepinephrine]] (noradrenaline) lalu na ing mismung ), keng β-[[adrenergic receptor]]s, dake ning  [[sympathetic nervous system]] nung nu iti ing mamagitan keng "[[laban o mamakong]]" pakibat. 

Atin atlung kebaluan a pinduan da reng receptor, mitulduan bilang β<sub>1</sub>, β<sub>2</sub> ampong  β<sub>3</sub>. β<sub>1</sub>-Deng adrenergic receptors keraklan atiu la keng [[pusu]] ampong [[batu]]. β<sub>2</sub>-Deng adrenergic receptors atiu la keraklan keng [[baga]], [[bituka]], [[ate]], [[palaanakan]] vascular smooth muscle, ampong  kalamnan keng [[bungu]]. β<sub>3</sub>-Deng receptors atiu la kareng taba da reng [[cells]].

Deng alimbawa da reng beta-blockers abe la reng : Sectral, Zebeta, Brevibloc, Inderal, Tenormine, Normodyne, Coreg, ampong Lopressor

=== β-Receptor panglaban ===
Ustung mayayapis la reng β<sub>1</sub> receptors kareng epinephrine iti maginduce lang positive [[chronotropic]] ampong [[inotropic]] a uyab keng pusu ampong dadakalan na ing cardiac conduction velocity ampong [[automaticity]]. Ing mayayapis a  β<sub>1</sub> receptors keng [[batu]] lulual la reng [[renin]]. Ing pangayapis da reng  β<sub>2</sub> receptors mipapainawa lang reng [[smooth muscle]]  (ing uyab na ing [[vasodilation]] ampong [[bronchodilation]] (pamamuklat da reng broncho), iti mikakagalgal keng [[kalamnan keng bungu]], ampong darakal ing [[glycogenolysis]] keng [[ate]] ampong [[kalamnan keng bungu]]. Ing pamanapis ning  β<sub>3</sub> receptors maging [[lipolysis]].

Deng Beta blockers sasabatan nala dening normal epinephrine-mediated [[sympathetic nervous system|sympathetic]] a gawa, dapot ditak mu ing uyab kareng makapainawa. Nung nu babawasan na ing uyab keng pangabigla/sikan a pamagpilit keng kabug ning pusu, ampong king kayang pangapisil, pangabuklat da reng uyat, ampong pamamuklat da reng [[bronchi]], ampong pangaritak ning galgal ampong pamaglaso keng [[glycogen]].


=== β<sub>2</sub>-Selective agents ===
* [[Butaxamine]] (weak α-adrenergic agonist activity)

== Side Effects / Kabulasan katataulian ==
* Mababang prisyun a daya
* Mabagal a pitig ning pusu
* Epamandagus ning daya
* kelan tudtud
* Pamagpalya ning pusu
* Asthma
* Sobrang kalungkutan
* Kelan libi o pamanalakad
* Kaibug manyuka
* Sakit buntuk
* Malilyu
* Pamamulikat

== Uauangis a impormasyun ==
=== Pharmacological a pamialiwa ===
* Deng agents a atin intrinsic sympathomimetic action (ISA)
** Acebutolol, carteolol, celiprolol, mepindolol, oxprenolol, pindolol 
* Deng agents a atin masdakal a aqueous solubility
** Atenolol, celiprolol, nadolol, sotalol
* Deng agents a a atin membrane stabilising pamangimut
** Acebutolol, betaxolol, pindolol, propranolol
* Deng agents atin [[antioxidant]] a uyab
** Carvedilol
** Nebivolol

=== Pawagang pamialiwa ===
* Deng Agents a mismung indicasyun para (pamagpalya ning pusu)[[cardiac arrhythmia]]
** [[Esmolol]], [[sotalol]]
* Deng Agents a mismung indicasyun para (pamagbara at pamagpalya ning pusu)[[[[congestive heart failure]]
** [[Bisoprolol]], [[carvedilol]], [[metoprolol|sustained-release metoprolol]], [[nebivolol]]
* Deng Agents a mismung indicasyun para (sakit keng mata)[[glaucoma]]
** [[Betaxolol]], [[carteolol]], [[levobunolol]], [[metipranolol]], [[timolol]]
* Deng Agents a mismung indicasyun para [[myocardial infarction]]
** [[Atenolol]], [[metoprolol]], [[propranolol]]
* Deng Agents a mismung indicasyun para (sobrang sakit ning buntuk)[[migraine]] prophylaxis
** [[Timolol]], [[propranolol]]

Ing [[Propranolol]] iya kabud a agenti a indicasyun para panglaban keng tremor, [[portal hypertension]] ampong esophageal variceal a pamandaya, ampong keng pamangamit kambe ning α-blocker a pamanulu keng [phaeochromocytoma]].<ref name="Rossi"/>

== dalerayan ==
* {{cite book |author=Katzung, Bertram G. |title=Basic & clinical pharmacology |edition=9th edition |publisher=Lange Medical Books/McGraw-Hill |location=New York |year=2004 |pages=130, table 9-3 |isbn=0-07-144097-6 |oclc= |doi=}}


== Suglung Palual ==
* [http://www.nytimes.com/2004/10/17/arts/music/17tind.html?ex=1270785600&en=37bef79604f97228&ei=5090&partner=rssuserland Better Playing Through Chemistry] by Blair Tindall, ''[[New York Times]]'', [[October 17]], [[2004]]. (Discussing the use of beta-blockers among professional musicians.)
* [http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2004/10/17/MNGB599PJC1.DTL Musicians using beta blockers] by Blair Tindall. Condensed version of above article.
* {{MeshName|beta-Adrenergic+Blockers}}

{{Beta blockers}}
{{Antiglaucoma preparations and miotics}}
{{Major Drug Groups}}
{{Receptor agonists and antagonists}}

[[Category:Beta blockers|*]]
[[Category:Antihypertensive agents]]