View source for Enzyme

[[File:GLO1 Homo sapiens small fast.gif|thumb|300px|right|Ing [[glyoxalase I]] ning tau. Adua lang ion ning [[zinc]] deng kailangan ba neng a-catalyze ning enzyme ing reaction anti ing makalto kareng mangabilug a kule ubi. Makalto ya anting [[space-filling model]] ing metung a [[enzyme inhibitor]] a ausan dang S-hexylglutathione, a sasapak/kakatmu kareng aduang active site.]].

Deng '''enzymes''' [[biomolecule]] lang mag-[[w:catalysis|catalyze]] (magpabilis) kareng [[chemical reaction]].<ref>Smith AD (Ed) ''et al.'' (1997) ''Oxford Dictionary of Biochemistry and Molecular Biology'' Oxford University Press. ISBN 0-19-854768-4</ref><ref>Garrett RH, Grisham CM. (1999) ''Biochemistry, Second Edition'' Saunders College Publishing. 426-427. ISBN 0-03-022318-0 </ref> Alus [[protina]] la ngan deng enzyme. Kareng reaksion da reng enzyme, ausan dong [[w:Substrate (biochemistry)|substrates]] deng [[molecule]] king umpisa ning prosesu. Potang kai, alilan no ning enzyme ba lang maging aliwang molecule, deng produktu. Mangailangan lang enzyme deng halus eganaganang prosesu king metung a cell bang mitaglus king kailaingan a bilis o salusu. Uling eksaktu lang mamiling substrate deng enzyme, at ditak la mu deng papabilisan dang reaksion ibat kareng dakal a pipamilinan, ing kabilugan da reng enzyme king metung a cell ing tutuldu nung sanung [[metabolic pathway]] ing mararapat king metung a cell. 

Anti reng eganaganang catalyst, gagana la reng enzyme kapamilatan ning pamagbaba king [[activation energy]] (''E''<sub>a</sub> or Δ''G''<sup>‡</sup>) ning reaction, ania bigla yang mitatas ing salusu ning reaction. Miliun lang besis/ukdung mas matas deng salusu da ring enzyme reaction kesa kareng katumbas a reaction a e me-catalyze. Kalupa da reng aliwang catalyst, e la magigisan deng enzyme kareng reaction a karelang ka-catalyze, at e ra alilan ing [[chemical equilibrium|equilibrium]] da reng reaction a reti. Nanupata, ing pamialiwa da reng enzyme kareng aliwang catalyst, misna lang eksaktu o partikular deti. Sasabian dang apat lang libung 4,000 biochemical reaction deng ka-catalyze da reng enzyme.<ref>{{cite journal|url=http://www.expasy.org/NAR/enz00.pdf|author= Bairoch A.|year= 2000|title= The ENZYME database in 2000 |journal=Nucleic Acids Res|volume=28|pages=304-305|pmid= 10592255|doi= 10.1093/nar/28.1.304 }}</ref> Ating ditak a [[RNA]] molecule, a ausan dang [[ribozyme]], a mag-catalyze kareng reaction, at metung yang maulagang alimbawa ing mapilang dake ning [[ribosome]].<ref>{{cite journal |author=Lilley D |title=Structure, folding and mechanisms of ribozymes |journal=Curr Opin Struct Biol |volume=15 |issue=3 |pages=313-23 |year=2005 |pmid=15919196 |doi=10.1016/j.sbi.2005.05.002}}</ref><ref>{{cite journal |author=Cech T |title=Structural biology. The ribosome is a ribozyme |journal=Science |volume=289 |issue=5481 |pages=878-9 |year=2000 |pmid=10960319 |doi=10.1126/science.289.5481.878}}</ref> Magpalto la muring catalysis a kalupa da reng enzyme deng pikudta o artipisial a molecule, a ausan dang [[artificial enzyme]].<ref>{{cite journal |author=Groves JT |title=Artificial enzymes. The importance of being selective |journal=Nature |volume=389 |issue=6649 |pages=329-30 |year=1997 |pmid=9311771 | doi = 10.1038/38602 <!--Retrieved from PMID by DOI bot-->}}</ref>

Mayayapektuan kareng aliwang molecule ing aktibidad da reng enzyme. Deng [[enzyme inhibitor|inhibitors]] molecule lang magpasikan king aktibidad. Enzyme inhibitor la reng dakal a [[panulu]] ampong [[lasun]]. Miyayapektuan murin ing aktibidad kareng [[temperatura]], paligid a kemikal (chemical environment, alimbawa ing [[pH]]), ampo ing [[w:concentration|tapang]] o konsentrasiun ning substrate. Gagamitan do king industria deng aliwang enzyme, alimbawa king king pamaglalang kareng [[antibiotic]]. Bukud kaniti, gagamit lang enzyme deng aliwang produktung gagamitan king bale (al., gagamitan do reng enzyme kareng biological [[washing powder]] a paglasong mantsang [[protina]] o [[taba]] kareng imalan; enzyme kareng pampalambut karni, bang mas malaguang langutan ing karni).  

== Lon la murin deti ==
* [[List of enzymes]]
* [[Enzyme assay]]
* [[Enzyme catalysis]]
* [[RNA Biocatalysis]]
* [[SUMO enzymes]]
* [[Ki Database|K<sub>i</sub> Database]]
* [[Proteonomics]] and [[protein engineering]]
* [[Immobilized enzyme]]

== Dalerayan ==
{{reflist|2}}

== Karagdagang babasan ==
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'''Etymology and history'''
* [http://bip.cnrs-mrs.fr/bip10/buchner.htm New Beer in an Old Bottle: Eduard Buchner and the Growth of Biochemical Knowledge, edited by Athel Cornish-Bowden and published by Universitat de València (1997): ISBN 84-370-3328-4] {{Wayback|url=http://bip.cnrs-mrs.fr/bip10/buchner.htm |date=20101213084345 }}, A history of early enzymology.
* [http://etext.lib.virginia.edu/toc/modeng/public/Wil4Sci.html Williams, Henry Smith, 1863–1943. A History of Science: in Five Volumes. Volume IV: Modern Development of the Chemical and Biological Sciences], A textbook from the 19th century.
* Kleyn, J. and Hough J. The Microbiology of Brewing. ''Annual Review of Microbiology'' (1971) Vol. 25: 583–608

'''Enzyme structure and mechanism'''
* Fersht, A. Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding. W. H. Freeman, 1998 ISBN 0-7167-3268-8
* Walsh, C., Enzymatic Reaction Mechanisms. W. H. Freeman and Company. 1979. ISBN 0-7167-0070-0
* Page, M. I., and Williams, A. (Eds.), 1987. Enzyme Mechanisms. Royal Society of Chemistry. ISBN 0-85186-947-5
* Bugg, T. Introduction to Enzyme and Coenzyme Chemistry, 2004, Blackwell Publishing Limited; 2nd edition. ISBN 1-4051-1452-5
* Warshel, A., Computer Modeling of Chemical Reactions in enzymes and Solutions John Wiley & Sons Inc. 1991. ISBN 0-471-18440-3

'''Thermodynamics'''
* [http://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookEnzym.html Reactions and Enzymes] Chapter 10 of On-Line Biology Book at Estrella Mountain Community College.

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'''Kinetics and inhibition'''
* Athel Cornish-Bowden, ''Fundamentals of Enzyme Kinetics''. (3rd edition), Portland Press (2004), ISBN 1-85578-158-1.
* Irwin H. Segel, ''Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems''. Wiley-Interscience; New Ed edition (1993), ISBN 0-471-30309-7.
* John W. Baynes, ''Medical Biochemistry'', Elsevier-Mosby; 2th Edition (2005), ISBN 0-7234-3341-0, p. 57.

'''Function and control of enzymes in the cell'''
* Price, N. and Stevens, L., Fundamentals of Enzymology: Cell and Molecular Biology of Catalytic Proteins Oxford University Press, (1999), ISBN 0-19-850229-X
* [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=gnd.chapter.86 Nutritional and Metabolic Diseases] Chapter of the on-line textbook "Introduction to Genes and Disease" from the NCBI.

'''Enzyme-naming conventions'''
* [http://www.chem.qmul.ac.uk/iubmb/enzyme/ Enzyme Nomenclature], Recommendations for enzyme names from the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.
* Koshland D. The Enzymes, v. I, ch. 7, Acad. Press, New York, (1959)

'''Industrial applications'''
* [http://www.mapsenzymes.com/History_of_Enzymes.asp History of industrial enzymes], Article about the history of industrial enzymes, from the late 1900s to the present times.

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== Suglung palual ==
{{commonscat|Enzymes}}
{{portal|Food}}
* [http://tutor.lscf.ucsb.edu/instdev/sears/biochemistry/tw-enz/tabs-enzymes-frames.htm Structure/Function of Enzymes], Web tutorial on enzyme structure and function.
* [http://www.science2day.info/2008/02/enzyme-test-or-cpk-test-what-is-it.html Enzymes in diagnosis] {{Wayback|url=http://www.science2day.info/2008/02/enzyme-test-or-cpk-test-what-is-it.html |date=20080612123407 }},Role of enzymes in diagnosis of diseases.
* [http://www.ebi.ac.uk/intenz/spotlight.jsp Enzyme spotlight] Monthly feature at the European Bioinformatics Institute on a selected enzyme.
* [http://www.amfep.org AMFEP], Association of Manufacturers and Formulators of Enzyme Products
* [http://www.brenda-enzymes.org BRENDA] database, a comprehensive compilation of information and literature references about all known enzymes; requires payment by commercial users.
* [http://www.ebi.ac.uk/thornton-srv/databases/enzymes/ Enzyme Structures Database] links to the known 3-D structure data of enzymes in the [[Protein Data Bank]].
* [http://us.expasy.org/enzyme/ ExPASy enzyme] database, links to [[Swiss-Prot]] sequence data, entries in other databases and to related literature searches.
* [http://www.genome.jp/kegg/ KEGG: Kyoto Encyclopedia of Genes and Genomes] Graphical and hypertext-based information on biochemical pathways and enzymes.
* [http://www-mitchell.ch.cam.ac.uk/macie MACiE] database of enzyme reaction mechanisms.
* [[MetaCyc]] database of enzymes and metabolic pathways
* [http://www.vega.org.uk/video/programme/19 'Face-to-Face Interview with Sir John Cornforth who was awarded a Nobel Prize for work on stereochemistry of enzyme-catalyzed reactions] Freeview video by the Vega Science Trust
* [http://www2.sigmaaldrich.com/Area_of_Interest/Biochemicals/Enzyme_Explorer/Key_Resources/Assay_Library/Assays_by_Enzyme_Name_IV.html?cm_mmc=wiki-_-social-_-enzymes-_-Enzymes Sigma Aldrich Enzyme Assays by Enzyme Name] {{Wayback|url=http://www2.sigmaaldrich.com/Area_of_Interest/Biochemicals/Enzyme_Explorer/Key_Resources/Assay_Library/Assays_by_Enzyme_Name_IV.html?cm_mmc=wiki-_-social-_-enzymes-_-Enzymes |date=20081006080938 }} - 100's of assays sorted by enzyme name. 

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{{Food chemistry}}
{{Enzymes}}

[[Category:Biomolecules]]
[[Category:Enzymes|*]]
[[Category:Metabolism]]